Michael B. Hoffman works in the industry of Law Firms & Legal Services. Michael B. Hoffman’s colleagues are Giancarlo Ruscio, Scott Semer, Na Fan, Kyle Kashuba. Viral integration transforms chromatin to drive oncogenesis. Michael M. Hoffman 101 College St PMCRT 11-311 Toronto, ON M5G 1L7 Work +1 416 581 7481 E-mail michael.hoffman@utoronto.ca ORCID 0000-0002-4517-1562 Current positions Scientist Princess Margaret Cancer Centre, Toronto, ON, 2013–present. First, we start with data from collaborators or public resources, using cancer cell lines and cancer patient primary tissue. xڽ\9�kK��B0���r�H!���\D��O�������؞�=k�sz��嫥�ۿ�웁��[v�y����w?�~��f���o?~��w�����'cb0&}��o�����j�������6ɟ���O0bx�[�>Ȁa!��`xN�U{�Oԧ�M�G���ٵvٞ��V�Z��2��2����@ "ԟ�����l0[I��ݥ��ʛ��}��l�i�*���s[,�f�u%+�܅w�q��/i
�5o��?�Kt�n>�e��}���2Hh��]��T��zm�M���3L߶;����`�������Ӻ��/��������f�n��`�i����m�J�ߒ,xw���퍥" Infosource We apply a systematic framework to create and validate predictive models of (1) how genetic variants cause epigenomic changes, and (2) the effect of epigenomic changes on gene regulation and phenotype. What is Michael B. Hoffman’s HQ phone number? View Dr. Hoffman's publication info on Google Scholar, Faculty of Medicine, University of Toronto © 2020 University of Toronto, Cancer Diagnosis and Therapy, Cancer Mechanisms and Models, Data Science and Computational Biology, Stem Cells and Regenerative Medicine, Faculty of Medicine, University of Toronto, Princess Margaret Cancer Research Tower, MaRS Centre, Image-Guided Therapy and Device Development, Mental Health Information for MBP Faculty, NIH K99/R00 Pathway to Independence Award. Recent projects have included (1) study of workers’ overoptimistic beliefs about their productivity, (2) an analysis of employee referral networks, and (3) an investigation of discretion in hiring. Segway enables simple interpretation and visualization of large multivariate genomic datasets. Segway analyzes multiple epigenomic datasets, integrates them, and categorizes each base in a genome (e.g. Profil détaillé de DAVID MICHAEL HOFFMAN, , 245 YORKLAND BLVD, STE. Virtual ChIP-seq: Predicting transcription factor binding by learning from the transcriptome. Oh! Déconnexion. Professor Mitchell Hoffman specializes in labor economics, behavioral economics, organizational economics, productivity, and strategy. 200 TORONTO, Ontario M2J1R1, TORONTO (Ontario) CAD keyboard_arrow_down. Save my name, email, and website in this browser for the next time I comment. Out of the Blue: A Film About Life and Football. 44 0 obj Your email address will not be published. Scroll down to bottom: https://t.co/iXf3LpTczB” In other work, I created Sunflower, a theoretical framework to predict effects of genetic variation on transcription factor (TF) binding, originating a widespread "motif-breaker" approach. Website feedback Michael Hoffman Senior Scientist at Princess Margaret Cancer Centre/Associate Professor at University of Toronto Toronto, Ontario, Canada 500+ connections “My letter to editor of Toronto Sun decrying call for Zundel to be in “agony,” was published. Milt Harris Library Segway's global impact is demonstrated by the many scientists who run the software or use our annotations on human cell types. Which industry does Michael B. Hoffman work in? Upcoming Events These annotations are displayed by both the Ensembl (50,000 unique users/week), and UCSC (38,000 unique/week) genome browsers. BEHST: genomic set enrichment analysis enhanced through integration of chromatin long-range interactions. “Segway 2.0: Gaussian mixture models and minibatch training.”, “Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet.”. �J�`p3���,D�. EN FR. Meet our Faculty He implemented the genome annotation method Segway, which simplifies interpretation of large multivariate genomic datasets, and was a linchpin of the NIH ENCODE Project analysis. ESS ��w�Sqr��c�AU��a�{Y�+��=���B�u"�~L�?���|u3��D��3ZQ����ɚ��3|����f����L��%��Y ��m91�L{�k��c�� �D,�� ���hvΦ�;��ɟ�wuc85��F(��V��db�Ug|�{3�*�Y�R���vhX�� Rotman Alumni Rotman School of Management Michael Hoffman creates predictive computational models to understand interactions between genome, epigenome, and phenotype in human cancers. He actively seeks out new partnerships and collaborations with organizations. Our lab develops machine learning techniques to better understand chromatin biology. Torys is headquartered in To, Information without innovation is just data, Michael B. Hoffman’s role in Torys LLP is Manager, Library Services, Michael B. Hoffman’s email address is m***@torys.com, Michael B. Hoffman’s business email address is m***@torys.com, Michael B. Hoffman’s direct phone number is (212) ***-****, Michael B. Hoffman’s HQ phone number is (416) 865-0040. Trouver une maison. What company does Michael B. Hoffman work for? He is married to Samantha Silva. He implemented the genome annotation method Segway, which simplifies interpretation of large multivariate genomic datasets, and was a linchpin of the NIH ENCODE Project analysis. Avec 57 noms retirés du Top 100 compilé par le journaliste senior de TSN Frank Seravalli, Mike Hoffman est maintenant le meilleur agent libre disponible. Data Science Applied Research and Education Seminar, Distinguished Lecture Series in Statistical Sciences, STAGE International Speaker Seminar Series, Banting-CANSSI Ontario Discovery Award in Data Science, Top-ups for Postdoctoral Fellows in Data Science, Banting-CANSSI Ontario Discovery Award in Data Science • U of T, Multidisciplinary Doctoral Training • U of T Department of Statistical Sciences. Our research program addresses this gap in knowledge to understand interactions between genome, epigenome, and phenotype in human cancers. Mon compte. Segway annotations also form a building block for highly-used noncoding interpretation tools like CADD and the Ensembl Regulatory Build. Canada, Founded in 1941, Torys is an international business law firm with a focus on serving the agribusiness, financial services, government, industrial, manufacturing, mining, oil, power, real estate, and technology industries. stream Trouver un courtier ou agent keyboard_arrow_down. Paramètres de mes notifications. Employer login Changes in gene regulation often underlie the mechanism of genetic disorders and cancer. New sequencing technology reveals a forest of genomic and epigenomic variation, but we are hindered by insufficient understanding of the variation's consequences. He is a director and writer, known for, U.K.’s National Film and TV School Returns to Production With Covid-Safe Shoots (Exclusive), Quentin Tarantino Makes Heartfelt Appearance to Celebrate Dp Robert Richardson in Poland. Your email address will not be published. Advances in research. Toronto, Ontario M5S 3E6 I transformed epigenomic analysis by creating the genome annotation method Segway. Assistant Professor Department of Medical Biophysics, University of Toronto, Toronto, ON, 2014–present. %���� Acknowledgements; Careers; Mailing List; News; Contact Us; Twitter.
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