Side Effects What are the side effects of Ondansetron (Zofran)?. There are no adequate studies of Zofran in pregnant women to determine its safe and effective use during pregnancy. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. The following article provides more detailed information on the use, side effects, and drawbacks of this drug. [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. Medically reviewed by Drugs.com. The only side effect is a headache,but it is tolerable compared to the nausea and vomiting that happen out of nowhere. © 2005 - 2019 WebMD LLC. Zofran is a drug with problematic side effects. Zofran is available in generic form. Ondansetron orally disintegrating tablet may cause drowsiness. Toxic Epidermal Necrolysis 17. Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown. If these effects persist or worsen, notify your doctor promptly. What Are Side Effects of Zofran? If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. Studies have linked Zofran to severe side effects, including birth defects, heart defects, cleft palate, and more. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Abnormal Liver Function Tests 3. 3. Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment. Life Threatening Allergic Reaction 11. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. If you struggle with nausea … Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Been unclear in many cases drawbacks of this drug for the treatment of postoperative and! It can also cause serious skeletal defects including deformed skulls that could have an impact on the of... To learn more about dosage and side effects: headache, feeling unwell ( malaise ) fatigue... 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